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ea0081p663 | Pituitary and Neuroendocrinology | ECE2022

GH-secreting pituitary adenoma: dura mater invasion is not a predictor of acromegaly persistence after trans-sphenoidal surgery

Prencipe Nunzia , Diperna Giuseppe , MARIA BERTON ALESSANDRO , Baldassarre Bianca , Bona Chiara , De Marco Raffaele , Bioletto Fabio , Grottoli Silvia , Zenga Francesco

Background: Despite the benign nature of pituitary adenomas, microscopic examination of surgical specimens showed that dural invasion occurs in about 42-85% of cases. No studies about dura mater invasion were conducted specifically in acromegaly, so the aim of the present study was to evaluate the relationship between histologically verified dural invasion and the aggressiveness features of GH-secreting adenomas.Methods: A prospective study i...

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ea0063p674 | Pituitary and Neuroendocrinology 2 | ECE2019

First and second day cortisol levels as predictors of long-term hypocortisolism after pituitary surgery

Prencipe Nunzia , Gasco Valentina , Gatti Filippo , Caputo Marina , D'Angelo Valentina , Bona Chiara , Caprino Mirko Parasiliti , Berton Alessandro Maria , Cambria Valeria , Penner Federica , Giordano Roberta , Ghigo Ezio , Zenga Francesco , Grottoli Silvia

Introduction: Prediction of HPA (hypothalamus-pituitary-adrenal) activity after trans-sphenoidal pituitary surgery (NS) is essential for post-operative management. There is not unique behavior in this setting: most of specialists suggests 4-6 weeks of glucocorticoid supplementation and treatment interruption after demonstration of normal endogenous response. Some authors suggest early cortisol detection for the identification of patients requiring glucocorticoid therapy. Aim o...

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Endocrine Abstracts

GH-secreting pituitary adenoma: dura mater invasion is not a predictor of acromegaly persistence after trans-sphenoidal surgery

First and second day cortisol levels as predictors of long-term hypocortisolism after pituitary surgery

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